FOLLOW-UP COLONOSCOPY QUALITY

The Cologuard® test can enrich follow-up colonoscopy patient populations1-4 

According to a study, 77% of patients adhere to colonoscopy after a positive Cologuard result. Additional studies have shown that positive Cologuard results can produce1-5:

Significantly higher rate of precancer diagnoses*

More clinically relevant precancer diagnoses

More histologically advanced findings

Enhanced CRC detection
5x
more CRC cases were found during colonoscopies following a positive stool-based test compared to screening colonoscopy alone

Cologuard-first screening can help prioritize colonoscopy for patients who need it most.1-4

Use the Cologuard test to help enhance the quality of detection of early-stage colorectal cancer (CRC) and precancer during follow-up colonoscopy.1,4

How Does Early Detection Lead to Colorectal Cancer Prevention?

Listen to a discussion about why stool-based options are uniquely positioned to detect precancer and early-stage CRC, helping providers intervene before cancer develops.

All panelists are paid speakers, presenting on behalf of Exact Sciences. Views, opinions, and information provided during this presentation are based on the speakers’ own clinical practice and experience and are not clinical, diagnostic, or treatment advice for any particular event. Exact Sciences does not recommend or endorse any particular course of treatment or medical choice.

View updated guidance for cost-sharing for a follow-up colonoscopy



  • *Overall neoplasia diagnosis in colonoscopies after a positive mt-sDNA test was 15% higher vs screening colonoscopy (47% vs 32%, respectively).4
  • Colonoscopies following positive mt-sDNA results detected 12% more clinically relevant serrated polyps vs colonoscopy only (20.9% vs 8.6%, respectively).2
  • Patients with positive mt-sDNA results had more histologically advanced findings vs those with positive FIT results (P=0.0054) and those who only underwent colonoscopy (P<0.0001).1
  • §Based on cross-sectional data for >1.73 million colonoscopies performed between 2019-2022, CRC detection rates were 0.3% for screening colonoscopy compared to 1.5% for colonoscopy following a positive FOBT or FIT-DNA test.6

FIT=fecal immunochemical test.