Regular colorectal cancer (CRC) screening may help
reduce mortality rates and has the potential to save lives1

The U.S. Preventive Services Task Force (USPSTF) now recommends screening patients at average risk for CRC starting at age 451

(Grade B recommendation)1*

Of the ~44 million average-risk patients
aged 45 and older eligible for CRC screening2:
~19 MILLIONMM

SCREENING-ELIGIBLE PATIENTS
ARE AGED 45 TO 49 YEARS2

Despite the American Cancer Society (ACS) lowering its initial screening age to 45 in 20183:

Only 1 in 5 patients aged 45 to 49 years recently reported screening for CRC4†
Initiating CRC screening at age 45 provides multiple benefits according to projection models, including averted CRC cases, a reduction in CRC-related deaths, and an increase in patient life-years gained.1
  • Incidence and severity in patients <50

    Among patients younger than 50 years*†:

    ~51%

    Increase in the incidence of CRC within a 20-year period (1994-2014)3

    ~52%

    Were diagnosed with more advanced stages of CRC vs 40% of patients aged 50+ years (2004-2015)5

    *

    The USPSTF found adequate evidence that screening patients aged 45 to 49 years provides a moderate benefit in reducing CRC deaths and increasing life-years gained. USPSTF-recommended screening modalities include stool-based tests or direct visualization tests.1

    The ACS makes a qualified recommendation for screening in patients aged 45 to 49 years, indicating clear evidence of benefit of screening but less certainty about the balance of benefits, harms, and patient preferences. ACS-recommended screening modalities include high-sensitivity stool-based tests or structural (visual) examinations.3


Early detection of CRC is vital

0

Symptoms

Many patients with early stage CRC have no symptoms and CRC is detected through screening6

90%

Survival rate

The 5-year relative survival rate (stages I and II)* is 90%, but when diagnosed in stage IV, that number drops to 14%7,8‡

5-year relative survival rates drastically diminish in later stages7,8§

5-year survival rates by stage of CRC7,8§:

STAGES I, IIA, IIB (Localized)7,8

90%

STAGES IIC, III (Regional)7,8

72%

STAGE IV (Distant)7,8

14%

Unfortunately, more than half of patients are diagnosed with regional or distant disease.7||

SCREENING FOR CRC ON TIME CAN LEAD TO EARLY DETECTION AND BETTER PATIENT OUTCOMES9