Noninvasive colorectal cancer (CRC) screening with Cologuard may address potential barriers for patients

  • Cologuard is shipped directly to patients' homes upon ordering.

    Accompanied by 2 months of personalized outreach to facilitate screening completion, including a welcome call as well as mail, email, or text message reminders.

    Cologuard kit

    The Cologuard Collection Kit

    The Cologuard collection kit is designed for ease of use at home. If a patient has questions, a customer support specialist is available to assist via phone at 1-844-870-8870.


  • Cologuard can be completed in the comfort of home and does not require special preparation, dietary or medication changes, sedation, or time off from work.

    • Patients should plan to collect their sample when they can get it back to UPS that same day or the next day
    • Patients should add a reminder to their calendars or phones for the day they will collect their sample

    The Customer Care Center is available 24/7 to help patients complete their Cologuard collection kit at 1-844-870-8870.

    How-to-use video

    How to use Cologuard

    See how patients can screen for CRC at home with Cologuard.

  • Patients can choose the no-cost return option that works best for them. They may:

    • Request a contact-free UPS® pickup: Call 1-844-870-8870 for help or visit to schedule it on their own
    • Drop it off at UPS: Visit to see local options and hours. Remember, some locations are closed on Sundays or holidays.

    Healthcare providers usually receive the test results within 2 weeks.

    Define results

    What do the results mean?


    A positive test result does not necessarily mean the patient has colorectal cancer. It means that Cologuard detected altered DNA and/or hemoglobin in the patient's stool. Patients with a positive result should have a follow-up colonoscopy.1


    A negative test result means that Cologuard did not detect altered DNA and/or hemoglobin in the stool. Patients with a negative result should continue in an appropriate screening program.1 The American Cancer Society recommends that patients get screened for colorectal cancer again 3 years after a negative Cologuard result.2


    Sample Could Not Be Processed (SCNBP) means that the sample received by the lab could not be processed for reasons such as: required labeling information was missing, buffer addition could not be verified, stool sample exceeds allowable weight, collection kit was damaged, an empty kit was received. For these, the patient will be contacted by Exact Sciences and a fax will be sent to the provider.


    No Result Obtained (NRO) means that a valid Cologuard result was not obtained for reasons such as: insufficient DNA volume, fecal hemoglobin sample did not produce a valid result, technical issues, etc. For these, the patient will be contacted by Exact Sciences and a fax will be sent to the provider.

    Reminder: Test results are provided to HCPs to communicate results with patients;
    results will only be delivered directly to the patient if specifically requested.

    False positives and false negatives do occur. In a clinical study, 13% of patients without colorectal cancer or advanced adenomas received a positive result (false positive) and 8% of patients with cancer received a negative result (false negative). Cologuard performance when used for repeat testing has not been evaluated or established.

3 Tips for Cologuard
collection kit completion

  • Reinforce with your patients the importance of early screening

    • Explain how early screening is important because when detected in early stages, CRC is more treatable1,3*
  • Ensure your patients understand the process

    • Let them know that they should expect a welcome call from the Customer Care Center
    • Recommend that they store the Cologuard collection kit on the back of their toilet until ready for use
    • Clarify with them what is considered an acceptable stool sample
      • It should not be larger than the bottle of liquid in the kit and should not be provided if there is diarrhea or blood in the stool
  • Provide tips and set expectations for collection kit completion

    • Provide a 2-week time frame for your patients to return the Cologuard collection kit
    • Explain how the sample should be shipped back within one day of collection and that patients should be mindful of weekends and holidays to prevent shipping delays

Ordering Cologuard via telehealth

Your patients can learn more about telehealth and, if they wish, also connect with a third-party telehealth provider at the Cologuard patient website, as a way to determine if Cologuard is right for them.