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Cologuard Plus specificity was 91% for category 3-6 and 94% in patients who had no precancerous polyps or CRC biopsied on colonoscopy when age-weighted to the US population.1*†

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Correct answer: True

Cologuard Plus specificity was 91% for category 3-6, and in patients who had no precancerous polyps or CRC biopsied on colonoscopy, specificity was 94% when age-weighted to the US population.1*†

References and footnotes

  • *The Cologuard Plus test was evaluated in a 2024, prospective, multicenter study of 26,758 patients aged 40 to 84 years asymptomatic for CRC. These data were determined from a subset of 18,911 average-risk patients 45 years and older. Screening colonoscopy was the reference method.1
  • †Cologuard Plus specificity: 91% specificity for category 3-6, including all participants who did not have advanced neoplasia. Specificity for no colorectal neoplasia was age-weighted to the US population and was defined as a negative colonoscopy, no adenocarcinoma of the colorectum, no adenomas, and no sessile serrated polyps/sessile serrated adenomas.1
  • 1.Cologuard Plus™ Clinician Brochure. Madison, WI: Exact Sciences Corporation.